Complement C1q tumor necrosis factor-related protein 5, C1qTNF5
Produced in E. coli. Recombinant mouse CTRP5 (Complement C1q tumor necrosis factor-related protein 5) (aa 16-243) is fused at the N-terminus to a linker peptide (14 aa) and a FLAG®-tag.
0.1mg/ml after reconstitution.
Lyophilized. Contains PBS.
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Shipped on Blue Ice
Long Term Storage:
Stable for at least 6 months after receipt when stored at -20°C.
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
CTRP5 is a member of the CTRP family designated as C1q tumor necrosis factor-related proteins. The CTRPs are paralogs of the adiponectin protein characterized by an N-terminus variable region and C-terminal globular domain (C1q). CTRP5 is a putative secreted protein. A mutation in CTRP5 gene has been genetically linked to the Late-onset retinal degeneration (L-ORD) disease which leads to severe visual loss.
Technical Info/Product Notes:
FLAG is a registered trademark of Sigma-Aldrich Co.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs: G.W. Wong, et al.; PNAS 101, 10302 (2004), Abstract;
Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration: C. Hayward, et al.; Hum. Mol. Genet. 12, 2657 (2003), Abstract;