Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Profilin (Toxoplasma gondii), (recombinant) (GST-tag)

TLR ligand
 
ALX-522-093-C010 10 µg 264.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:Inflammatory profilin, Toll-like receptor 11 ligand, TLR11 ligand
 
Sequence:aa (1-163)
 
MW:~47kDa
 
Source:Produced in E. coli. Full length profilin (aa 1-163) from Toxoplasma gondii is fused to an N-terminal GST-tag.
 
UniProt ID:Q58NA1
 
Concentration:0.1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Associates of Cape Cod).
 
Reconstitution:Reconstitute with 100µl sterile, endotoxin-free water. Further dilutions should be made with medium containing 5% fetal calf serum.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Scientific Background:The initial recognition of pathogens during host defense is mediated by a family of receptors termed toll-like receptors (TLR). TLRs recognize conserved microbial components, termed pathogen-associated molecular patterns (PAMPs). To date, 11 TLRs have been cloned in mammals and each receptor appears to be involved in the recognition of a unique set of PAMPs that are distinct in their chemical nature and structure. TLR11 has a role in uropathogenic E. coli infection and senses the profilin protein from the protozoan parasite Toxoplasma gondii. Profilins are a class of small actin-binding proteins present only in eukaryotic cells. T. gondii profilin shares significant homology only with profilin genes from other apicomplexan protozoa, such as the malaria parasite, Plasmodium falciparum, suggesting that TLR11 may be involved in the recognition of these parasites. Profilin activates and induces TLR11-dependent IL-12p40 production from dendritic cells, and is known to bind TLR11 from mouse.
 

General Literature References

Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response: F. Yarovinsky, et al.; Immunity 25, 655 (2006), Abstract;
Of mice and man: TLR11 (finally) finds profilin: F.N. Lauw, et al.; Trends Immunol. 26, 509 (2005), Abstract;
TLR11 activation of dendritic cells by a protozoan profilin-like protein: F. Yarovinsky, et al.; Science 308, 1626 (2005), Abstract;
A toll-like receptor that prevents infection by uropathogenic bacteria: D. Zhang, et al.; Science 303, 1522 (2004), Abstract;

Related Products

ddWater (endotoxin-free) 

7732-18-5 | Print as PDF
 
ALX-505-008-LD15 1.5 ml 38.00 USD
Do you need bulk/larger quantities?
 

PBS (endotoxin-free) 

Print as PDF
 
ALX-505-007-LD15 1.5 ml 54.00 USD
 
ALX-505-007-L010 10 ml 102.00 USD
Do you need bulk/larger quantities?
 

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Profilin
TLR
By biological activity:
Profilin Recombinant protein
TLR Ligand
TLR Activator
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Brochures
Innovative Products to Analyze Immunological Disorders
Innovative Products to Analyze Immunological Disorders
Download as PDF

Product Flyers
Key TLR Ligands and their Receptors
Key TLR Ligands and their Receptors
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,