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Toll-like receptor 6 (mouse) (24-594):Fc (human), (recombinant)

 
ALX-522-075-C050 50 µg 412.00 USD
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Product Specification

Alternative Name:TLR6, CD286
 
MW:~140kDa (SDS-PAGE).
 
Source:Produced in HEK 293 cells. The extracellular domain of mouse TLR6 (aa 24-594) is fused at the C-terminus to the Fc portion of human IgG1 and a linker peptide (10 aa).
 
UniProt ID:Q9EPW9
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥90% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 

General Literature References

Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like [...]: Y. Bulut, et al.; J. Immunol. 167, 987 (2001), Abstract; Full Text
Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin: A.M. Hajjar, et al.; J. Immunol. 166, 15 (2001), Abstract; Full Text
Discrimination of bacterial lipoproteins by Toll-like receptor 6: O. Takeuchi, et al.; Int. Immunol. 13, 933 (2001), Abstract; Full Text
TLR6: A novel member of an expanding toll-like receptor family: O. Takeuchi, et al.; Gene 231, 59 (1999), Abstract;

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