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Toll-like receptor 4 (mouse) (24-334):Fc (human), (recombinant)

 
ALX-522-073-C050 50 µg 339.00 USD
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Product Specification

Alternative Name:TLR4, CD284
 
MW:~83kDa (SDS-PAGE).
 
Source:Produced in HEK 293 cells. The N-terminal region of the extracellular domain of mouse TLR4 (aa 24-334) is fused at the C-terminus to the Fc portion of human IgG1 and a linker peptide (2 aa).
 
UniProt ID:Q9QUK6, Q8K2T5
 
GenBank ID:AAH29856
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥90% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 

Product Literature References

Recognization of receptors on bone marrow-derived dendritic cells bound with Pholiota nameko polysaccharides: H. Li, et al.; Int. J. Biol. Macromol. 72, 649 (2015), Abstract;
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy: L. Apetoh, et al.; Nat. Med. 13, 1050 (2007), Abstract;

General Literature References

TLR4 as the mammalian endotoxin sensor: B. Beutler; Curr. Top. Microbiol. Immunol. 270, 109 (2002), (Review), Abstract;
Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction: J.C. Chow, et al.; J. Biol. Chem. 274, 10689 (1999), Abstract; Full Text
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene: A. Poltorak, et al.; Science 282, 2085 (1998), Abstract;
Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region: A. Poltorak, et al.; Blood Cells Mol. Dis. 24, 340 (1998), Abstract;

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