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IL-1 receptor type I (human):Fc (human), (recombinant)

 
ALX-522-057-C050 50 µg 398.00 USD
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Product Specification

Alternative Name:IL-1RI, Interleukin-1 receptor type I, CD121a
 
MW:~83kDa (SDS-PAGE).
 
Source:Produced in HEK 293 cells. Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused to the Fc portion of human IgG1.
 
UniProt ID:P14778
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥90% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Lonza).
 
Specificity:Binds to human IL-1 (interleukin-1).
 
Reconstitution:Reconstitute with 50µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Technical Info/Product Notes:Historical data has shown that IL-1 receptor blocks IL-1 activity.
 
522-057
Figure: Inhibition of IL-1 (Prod. No. ALX-522-056) induced NF-kB activation by IL-1R:Fc. The degradation of IkBa upon IL-1 stimulation previously incubated with IL-1R:Fc was measured by Western blot.  
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General Literature References

IL-1 and IL-18 receptors, and their extended family: J.E. Sims, et al.; Curr. Opin. Immunol. 14, 117 (2002), Abstract;
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense: L.A. O'Neill; Sci. STKE 2000, RE1 (2000), Abstract;
Cytokine receptors and signal transduction: A. Miyajima, et al.; Annu. Rev. Immunol. 10, 295 (1992), Abstract;
cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily: J.E. Sims, et al.; Science 241, 585 (1988), Abstract;

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