Product Details
| Alternative Name: | NGFR, TNFRSF 16, Low-affinity nerve growth factor receptor, p75NTR, p75 neurotrophin receptor, CD271 |
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| MW: | ~80kDa (under reducing conditions). |
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| Source: | Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75NTR) (aa 1-250) is fused to the Fc portion of human IgG1. |
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| UniProt ID: | P08138 |
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| Concentration: | 1mg/ml after reconstitution. |
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| Formulation: | Lyophilized. Contains PBS. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Endotoxin Content: | <0.1EU/µg purified protein (LAL test; Bio Whittaker). |
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| Species reactivity: | Human, Mouse, Rat
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| Specificity: | Binds human, mouse and rat NGF (nerve growth factor). |
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| Reconstitution: | Reconstitute in 50µl sterile water. Further dilutions can be made with medium containing 5% fetal calf serum. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. After reconstitution, it is recommended to make appropriate aliquots and to store them at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Technical Info/Product Notes: | Historical data has shown that NGFR inhibits rat NGF-mediated activation of rat PC12 cells. |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
Neurotrophins in cell survival/death decisions: P. Casaccia-Bonnefil, et al.; Adv. Exp. Med. Biol.
468, 275 (1999),
Abstract;
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