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Nerve growth factor receptor (human):Fc (human), (recombinant)

 
ALX-522-044-C050 50 µg 396.00 USD
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Product Specification

Alternative Name:NGFR, TNFRSF 16, Low-affinity nerve growth factor receptor, p75NTR, p75 neurotrophin receptor, CD271
 
MW:~80kDa (under reducing conditions).
 
Source:Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75NTR) (aa 1-250) is fused to the Fc portion of human IgG1.
 
UniProt ID:P08138
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥90% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Species reactivity:Human, Mouse, Rat
 
Specificity:Binds human, mouse and rat NGF (nerve growth factor).
 
Reconstitution:Reconstitute in 50µl sterile water. Further dilutions can be made with medium containing 5% fetal calf serum.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C. After reconstitution, it is recommended to make appropriate aliquots and to store them at -20°C.
 
Handling:Avoid freeze/thaw cycles.
 
Technical Info/Product Notes:Historical data has shown that NGFR inhibits rat NGF-mediated activation of rat PC12 cells.
 

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General Literature References

Neurotrophins in cell survival/death decisions: P. Casaccia-Bonnefil, et al.; Adv. Exp. Med. Biol. 468, 275 (1999), Abstract;

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