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RANK (human):Fc (human), (recombinant)

 
ALX-522-039-C050 50 µg 408.00 USD
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Product Specification

Alternative Name:TRANCE-R, TNFRSF 11A, ODFR, CD265
 
MW:~55kDa (SDS-PAGE).
 
Source:Produced in HEK 293 cells. The cysteine-rich region of human RANK (aa 29-213) is fused to the Fc portion of human IgG1.
 
UniProt ID:Q9Y6Q6
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Species reactivity:Human, Mouse
 
Specificity:Binds human and mouse RANKL.
 
Applications:ELISA
 
Application Notes:ELISA: binds to RANKL.
 
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C. Once reconstituted, it is recommended to prepare appropriate aliquots and to store them at -20°C.
 
Handling:Avoid freeze/thaw cycles.
 
Scientific Background:The receptor activator of NF-κB (RANK) is a member of the tumor necrosis factor receptor (TNF-R) family. RANK is a type I transmembrane receptor. It is 616 aa long and contains 4 cysteine-rich motifs in its extracellular domain, while its long cytoplasmic domain spans 383 aa. RANK is mainly expressed on dendritic cells. After binding its ligand RANKL, RANK interacts with TNF receptor-associated factor 1 (TRAF1), TRAF2, TRAF3, TRAF5 and TRAF6 which mediate activation of nuclear factor NF-κB and JNK. RANK-RANKL interactions promote survival of dendritic cells as well as differentiation in osteoclasts. Historical data has shown that RANK inhibits human rhsRANKL-induced survival of dendritic cells and osteoclasts.
 

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