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LTα3 (soluble) (human), (recombinant)

 
ALX-522-034-C010 10 µg 287.00 USD
 
ALX-522-034-3010 3x10 µg SuperPack 557.00 USD
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Product Specification

Alternative Name:TNF-β, TNFSF 1, Tumor necrosis factor β
 
MW:~25kDa (SDS-PAGE).
 
Source:Produced in E. coli. The extracellular domain of human LTα3 (aa 43-205) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
 
UniProt ID:P01374
 
Concentration:0.1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Species reactivity:Human, Mouse
 
Specificity:Binds to human HVEM and human and mouse TNF-R1 and TNF-R2.
 
Reconstitution:Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles.
 
Scientific Background:Lymphotoxin-α (LTα, TNF-β) is a 25 kDa type II soluble protein belonging to the TNF family. It is expressed as a trimer (LTα3), or with lymphotoxin-β (LTα1β2 or LTα2β1). LTα3 interacts with 3 different members of the TNF-receptor superfamily: HVEM (Prod. No. ALX-522-017), TNF-R1 (Prod. No. ALX-522-013) and TNF-R2 (Prod. No. ALX-522-014). LTα3 is expressed by activated T and B lymphocytes and is a pro-apoptotic cytokine, a pluripotent mediator of inflammtory and immune defense mechanisms, and moreover it plays an important role in regulating the generation of the peripheral lymphoid system. Historical data has shown that LTα3 kills human TNF-R1 positive cells.
 
Technical Info/Product Notes:FLAG is a registered trademark of Sigma-Aldrich Co.
 

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