| ALX-522-031-C050 | 50 µg | 518.00 USD |  |
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| Alternative Name: | 4-1BB, TNFRSF 9 |
| MW: | ~50kDa (SDS-PAGE). |
| Source: | Produced in HEK 293 cells. The cysteine-rich region of human CD137 (4-1BB) (aa 1-186) is fused to the Fc portion of human IgG1. |
| UniProt ID: | Q07011 |
| Concentration: | 1mg/ml after reconstitution. |
| Formulation: | Lyophilized. Contains PBS. |
| Purity: | ≥95% (SDS-PAGE) |
| Endotoxin Content: | <0.1EU/µg purified protein (LAL test; Associates of Cape Cod). |
| Specificity: | Binds human CD137L (4-1BBL). |
| Applications: | ELISA, FUNC |
| Application Notes: | ELISA: binds to CD137L at 10-100 ng/ml. Can be used together with anti-human IgG1 PAb to detect membrane-bound human CD137. Functional Application: Induces proliferation of monocytes. Note: Induction of monocyte proliferation by CD137 required immobilization of the CD137 protein, e.g. by coating of the protein to the surface of the tissue culture dishes. |
| Reconstitution: | Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
| Regulatory Status: | RUO - Research Use Only |
Control:Fc fusion protein (human), (recombinant) |
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| Negative control for Fc chimeric proteins | ||||||
| Produced in HEK 293 cells. The extracellular domain of mutated hThy-1, hThy-1 (RLE) (aa 20-130), is fused to the Fc portion of human IgG1. The integrin binding sequence RLD of hThy-1 has been changed to RLE abolishing the binding of integrins., ≥90% (SDS-PAGE) | Print as PDF | ||||||
| ALX-203-004-C050 | 50 µg | 532.00 USD | |
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