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CD137 (human):Fc (human), (recombinant)

 
ALX-522-031-C050 50 µg 393.00 USD
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Product Specification

Alternative Name:4-1BB, TNFRSF 9
 
MW:~50kDa (SDS-PAGE).
 
Source:Produced in HEK 293 cells. The cysteine-rich region of human CD137 (4-1BB) (aa 1-186) is fused to the Fc portion of human IgG1.
 
UniProt ID:Q07011
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Associates of Cape Cod).
 
Specificity:Binds human CD137L (4-1BBL).
 
Applications:ELISA, FUNC
 
Application Notes:ELISA: binds to CD137L at 10-100 ng/ml.
Can be used together with anti-human IgG1 PAb to detect membrane-bound human CD137.
Functional Application: Induces proliferation of monocytes.
Note: Induction of monocyte proliferation by CD137 required immobilization of the CD137 protein, e.g. by coating of the protein to the surface of the tissue culture dishes.
 
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 

Product Literature References

CD 137 induces proliferation and endomitosis in monocytes: J. Langstein, et al.; Blood 94, 3161 (1999), Abstract;

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