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GITR (mouse):Fc (human), (recombinant)

 
ALX-522-024-C050 50 µg 365.00 USD
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Product Specification

Alternative Name:AITR, TNFRSF 18, Glucocorticoid-induced TNFR-related protein, Activation-inducible TNFR family receptor
 
MW:~45kDa (SDS-PAGE).
 
Source:Produced in HEK 293 cells. The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1.
 
UniProt ID:O35714
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Specificity:Binds mouse GITRL.
 
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 

Product Literature References

Identification of glucocorticoid-induced TNF receptor-related protein ligand on keratinocytes: ligation by GITR induces keratinocyte chemokine production and augments T-cell proliferation: A.M. Byrne, et al.; J. Invest. Dermatol. 129, 2784 (2009), Abstract; Full Text
Proinflammatory role of glucocorticoid-induced TNF receptor-related gene in acute lung inflammation: S. Cuzzocrea, et al.; J. Immunol. 177, 631 (2006), Abstract;
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) stimulates osteoclast differentiation in response to receptor activator of NF-kappaB ligand (RANKL) in osteoclast cells: H.H. Shin, et al.; Bone 36, 832 (2005), Abstract;
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells: M. Tone, et al.; PNAS 100, 15059 (2003), Abstract;
Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice: H. H. Shin, et al.; Exp. Mol. Med. 35, 358 (2003), Abstract; Full Text

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