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CD134L (soluble) (human), (recombinant)

 
ALX-522-023-C010 10 µg 273.00 USD
 
ALX-522-023-3010 3x10 µg SuperPack 512.00 USD
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Product Specification

Alternative Name:OX40L, TNFSF 4, CD252
 
MW:~30kDa (SDS-PAGE).
 
Source:Produced in HEK 293 cells. The extracellular domain of human CD134L (OX40L) (aa 52-183) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
 
UniProt ID:P23510
 
Concentration:0.1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity Detail:Purified by single-step affinity chromatography.
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Specificity:Binds to human CD134 (OX40).
 
Applications:ELISA
 
Application Notes:ELISA: binds to CD134 receptor).
Can be used together with anti-FLAG® MAb to detect membrane-bound human CD134 (OX40).
 
Reconstitution:Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -80°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
 
Technical Info/Product Notes:Historical data indicates that CD134L activates T cell proliferation and delays neutrophil apoptosis.

FLAG is a registered trademark of Sigma-Aldrich Co.
 

Product Literature References

Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand: J. Dannull, et al.; Blood 105, 3206 (2005), Abstract;
Functional expression of CD134 by neutrophils: R. Baumann, et al.; Eur. J. Immunol. 34, 2268 (2004), Abstract;

General Literature References

Functional expression of CD134 by neutrophils: R. Baumann, et al.; Eur. J. Immunol. 34, 2268 (2004), Abstract;
CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells: H. Akiba, et al.; J. Immunol. 162, 7058 (1999), Abstract;
CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles: T. Brocker, et al.; Eur. J. Immunol. 29, 1610 (1999), Abstract;
OX40-Mediated cosignal enhances the maturation of naive human CD4+ T cells into high IL-4-producing effectors: G. Delespesse, et al.; Int. Arch. Allergy Immunol. 118, 384 (1999), Abstract;
Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses: I. Gramaglia, et al.; J. Immunol. 161, 6510 (1998), Abstract;

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