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TNF-R1 (human):Fc (human), (recombinant)

 
ALX-522-013-C050 50 µg 402.00 USD
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Product Specification

Alternative Name:p55, CD120a, TNF-R 60kDa, TNFRSF 1A
 
MW:~60kDa (reducing SDS-PAGE).
 
Source:Produced in HEK 293 cells. The extracellular domain of human TNF-R1 (aa 1-211) is fused to the Fc portion of human IgG1.
 
UniProt ID:P19438
 
Concentration:1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Species reactivity:Human, Mouse
 
Specificity:Binds human and mouse TNF-α (tumor necrosis factor-a).
 
Applications:ELISA
 
Application Notes:ELISA: binds to TNF-α.
 
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or carrier protein.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Technical Info/Product Notes:Previous data has shown that TNF-R1 receptor binds to TNF-R1 and triggers various biological effects (including cell death). rhTNF-R1:Fc fusion protein blocks TNF-α-mediated lysis with a inhibitory activity in a concentration range of 10-50ng/ml using Wehi cells.
 
522.013
Figure: Inhibition of TNF-mediated lysis of WEHI 164 target cells (rhsTNF-a, Prod. No. ALX-522-008). rhTNF-R1:Fc exerts its inhibitory activity in a concentration range of 10-50ng/ml.
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522.013

Product Literature References

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8: M.A. Laussmann, et al.; Cell Death Differ. 18, 1584 (2011), Abstract;
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors: N. Holler, et al.; J. Immunol. Methods 237, 159 (2000), Abstract;
The lymphotoxin-β receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells: I.A. Rooney, et al.; J. Biol. Chem. 275, 13047 (2000), Abstract; Full Text

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