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TRAIL-R1 (human):Fc (human), (recombinant)

ALX-522-004-C050 50 µg 331.00 USD
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Product Specification

Alternative Name:DR4, CD261, TNFRSF 10A
MW:~54kDa (SDS-PAGE).
Source:Produced in HEK 293 cells. The extracellular domain of human TRAIL-R1 (DR4) (aa 24-239) is fused to the Fc portion of human IgG1.
UniProt ID:O00220
Concentration:1mg/ml after reconstitution.
Formulation:Lyophilized. Contains PBS
Purity:≥95% (SDS-PAGE)
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Species reactivity:Human, Mouse
Specificity:Binds human and mouse TRAIL.
Biological Activity:Inhibits human soluble TRAIL-mediated apoptosis in a concentration range of 2-10µg/ml. Use TRAIL-R2 (human):Fc (human) (rec.) (Prod. No. ALX-522-005) for the detection of human surface TRAIL by FC.
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

Product Literature References

Serine 574 phosphorylation alters transcriptional programming of FOXO3 by selectively enhancing apoptotic gene expression: Z. Li, et al.; Cell Death Differ. 23, 583 (2016), Abstract;
Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8: M.A. Laussmann, et al.; Cell Death Differ. 18, 1584 (2011), Abstract;
TRAIL-related death receptors in normal, Lurcher and weaver mutant mouse brain: J. Baurle, et al.; Neurosci. Lett. 372, 46 (2004), Abstract;
T cell costimulation by the TNF ligand BAFF: B. Huard, et al.; J. Immunol. 167, 6225 (2001), Abstract;
The lymphotoxin-β receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells: I.A. Rooney, et al.; J. Biol. Chem. 275, 14307 (2000), Abstract; Full Text
The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation: F. Mühlenbeck et al.; J. Biol. Chem. 275, 32208 (2000), Abstract; Full Text

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