Gemcitabine . hydrochloride

DNA synthesis inhibitor



ALX-480-101-M025	25 mg	76.00 USD

ALX-480-101-M100	100 mg	248.00 USD

Deoxycytidine analog with cytotoxic effects. Induces apoptosis and inhibits DNA synthesis.

Product Specification

Alternative Name:	2’-Deoxy-2’,2’-difluorocytidine . HCl, LY-188011 . HCl

Formula:	C₉H₁₁F₂N₃O₄. HCl

MW:	263.2 . 36.5

Purity:	≥98% (Assay)

Appearance:	White to off-white crystalline powder.

CAS:	122111-03-9

MI:	14: 4386

RTECS:	HA3840000

Source/Host:	Synthetic.

Solubility:	Soluble in water; slightly soluble in methanol; almost insoluble in 100% ethanol or polar organic solvents.

Long Term Storage:	+4°C

Hazard:	HARMFUL.

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Product Literature References

Cellular pharmacology of gemcitabine: E. Mini, et al.; Ann. Oncol. 17, v7 (2006), Abstract; Full Text

Gemcitabine: a cytidine analogue active against solid tumors: Y.F. Hui & J. Reitz; Am. J. Health Syst. Pharm. 54, 162 (1997), Abstract;

Gemcitabine: metabolism, mechanisms of action, and self-potentiation: W. Plunkett, et al.; Semin. Oncol. 22, 3 (1995), Abstract;

Cellular elimination of 2’,2’-difluorodeoxycytidine 5’-triphosphate: a mechanism of self-potentiation: V. Heinemann, et al.; Cancer Res. 52, 533 (1992), Abstract; Full Text