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Gemcitabine . hydrochloride

DNA synthesis inhibitor
 
ALX-480-101-M025 25 mg 88.00 USD
 
ALX-480-101-M100 100 mg 289.00 USD
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Deoxycytidine analog with cytotoxic effects. Induces apoptosis and inhibits DNA synthesis.

Product Specification

Alternative Name:2’-Deoxy-2’,2’-difluorocytidine . HCl, LY-188011 . HCl
 
Formula:C9H11F2N3O4 . HCl
 
MW:263.2 . 36.5
 
Source:Synthetic.
 
CAS:122111-03-9
 
MI:14: 4386
 
RTECS:HA3840000
 
Purity:≥97.5% (Assay)
 
Identity:Determined by IR.
 
Appearance:White to off-white crystalline powder.
 
Solubility:Soluble in water; slightly soluble in methanol; almost insoluble in 100% ethanol or polar organic solvents.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
480-101
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480-101

Product Literature References

Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673: A.Z. Andrei, et al.; Cancer Lett. 364, 8 (2015), Application(s): Cell Culture, Abstract;
Cellular pharmacology of gemcitabine: E. Mini, et al.; Ann. Oncol. 17, v7 (2006), Abstract; Full Text
Gemcitabine: a cytidine analogue active against solid tumors: Y.F. Hui & J. Reitz; Am. J. Health Syst. Pharm. 54, 162 (1997), Abstract;
Gemcitabine: metabolism, mechanisms of action, and self-potentiation: W. Plunkett, et al.; Semin. Oncol. 22, 3 (1995), Abstract;
Cellular elimination of 2’,2’-difluorodeoxycytidine 5’-triphosphate: a mechanism of self-potentiation: V. Heinemann, et al.; Cancer Res. 52, 533 (1992), Abstract; Full Text

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