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Fludarabine

F-ara-A precursor
 
ALX-480-100-M005 5 mg 53.00 USD
 
ALX-480-100-M025 25 mg 199.00 USD
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Prodrug converted to the free nucleoside 9-β-D-arabinosyl-2-fluoroadenine (F-ara-A). F-ara-A enters cells and accumulates as the 5'-triphosphate. Interferes with DNA synthesis and repair. Induces apoptosis of cancer cells. Inhibits RNA transcription.

Product Specification

Alternative Name:2-Fluoroadenine-9-β-D-arabinofuranoside
 
Formula:C10H12FN5O4
 
MW:285.2
 
CAS:21679-14-1
 
MI:14: 4126
 
RTECS:AU6207000
 
Purity:≥98% (HPLC)
 
Identity:Determined by IR.
 
Appearance:White to pale yellow crystalline powder.
 
Solubility:Sparingly soluble in water or organic solvents.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
480-100
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480-100

Product Literature References

Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway: C. Nishioka, et al.; Leukemia 21, 1044 (2007), Abstract;
Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells: C. Pepper, et al.; Br. J. Cancer 97, 253 (2007), Abstract;
Role of fludarabine in hematological malignancies: M. Montillo, et al.; Expert Rev. Anticancer Ther. 6, 1141 (2006), Abstract;
Inhibition of RNA transcription: a biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine: P. Huang, et al.; Leukemia 14, 1405 (2000), Abstract;
Action of 9-beta-D-arabinofuranosyl-2-fluoroadenine on RNA metabolism: P. Huang & W. Plunkett; Mol. Pharmacol. 39, 449 (1991), Abstract;
Termination of DNA synthesis by 9-beta-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity: P. Huang, et al.; J. Biol. Chem. 265, 16617 (1990), Abstract; Full Text
Fludarabine: a new agent with major activity against chronic lymphocytic leukemia: M.J. Keating, et al.; Blood 74, 19 (1989), Abstract; Full Text

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