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5-Fluorouracil

Thymidylate synthetase inhibitor
 
ALX-480-099-G005 5 g 72.00 USD
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Potent antitumor agent. Inhibits thymidylate synthetase. Induces p53-dependent apoptosis.

Product Specification

Alternative Name:5-FU, 2,4-Dioxo-5-fluoropyrimidine, 5-Fluoro-2,4(1H,3H)-pyrimidinedione
 
Formula:C4H3FN2O2
 
MW:130.1
 
CAS:51-21-8
 
MI:14: 4181
 
RTECS:YR0350000
 
Purity:≥98% (HPLC)
 
Identity:Determined by IR.
 
Appearance:White to off-white crystalline powder.
 
Solubility:Soluble in DMSO (5mg/ml), dimethyl formamide (5mg/ml), methanol (1mg/ml) or hot water (1mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
480-099
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Product Literature References

PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract; Full Text
5-fluorouracil sensitivity and dihydropyrimidine dehydrogenase activity in advanced gastric cancer: T. Inada, et al.; Anticancer Res. 20, 2457 (2000), Abstract;
Effect of 5-fluorouracil on cell cycle regulatory proteins in human colon cancer cell line: H. Takeda, et al.; Jpn. J. Cancer Res. 90, 677 (1999), Abstract;
Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity: D.M. Pritchard, et al.; Toxicol. Lett. 102, 19 (1998), Abstract;
Effects of perturbations of pools of deoxyribonucleoside triphosphates on expression of ribonucleotide reductase, a G1/S transition state enzyme, in p53-mutated cells: S. Wadler, et al.; Biochem. Pharmacol. 55, 1353 (1998), Abstract;
Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells: K.H. Elstein, et al.; Toxicol. Appl. Pharmacol. 146, 29 (1997), Abstract;
Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis: J. Pressacco, et al.; Br. J. Cancer 72, 939 (1995), Abstract;
Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia: I.B. Shchepotin, et al.; Anticancer Res. 14, 1027 (1994), Abstract;

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