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Loxoribine

TLR ligand
 
ALX-480-097-M025 25 mg 145.00 USD
 
ALX-480-097-M100 100 mg 441.00 USD
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Selective ligand for Toll-like receptor 7 (TLR7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2.

Product Specification

Alternative Name:7-Allyl-8-oxoguanosine, RWJ 21757
 
Formula:C13H17N5O6
 
MW:339.3
 
CAS:121288-39-9
 
Purity:≥97% (HPLC (UV))
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (30mg/ml), water (10mg/ml), water:acetonitrile (1:1) (20mg/ml) or water:methanol (1:1) (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
480-097
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Product Literature References

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases: A. Kanno, et al.; Nat. Commun. 6, 6119 (2015), Application(s): Cell Culture, Abstract;
Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN: I.B. Bekeredjian-Ding, et al.; J. Immunol. 174, 4043 (2005), Abstract; Full Text
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7: J. Lee, et al.; PNAS 100, 6646 (2003), Abstract; Full Text
The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines: B.L. Pope, et al.; Cell. Immunol. 162, 333 (1995), Abstract;
Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle: M.G. Goodman, et al.; Blood 84, 3457 (1994), Abstract; Full Text
Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression: U. Schindler and V.R. Baichwal; Mol. Cell. Biol. 14, 5820 (1994), Abstract; Full Text
Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2: B.L. Pope, et al.; J. Immunol. 151, 3007 (1993), Abstract;

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