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ADP-HPD . ammonium salt . dihydrate

PARG inhibitor
 
ALX-480-094-C060 60 µg 248.00 USD
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Potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50=120nM) versus ADP-ribose (IC50=120µM). Does not affect the activities of either PARP-1 or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1mM concentration.

Product Specification

Alternative Name:Adenosine 5'-diphosphate (hydroxymethyl) pyrrolidinediol . NH4 . 2H2O
 
Formula:C15H23N6O12P2 . NH4 . 2H2O
 
MW:541.3 . 18.0 . 36.0
 
Formulation:Lyophilized
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white amorphous solid.
 
Solubility:Soluble in water (5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Packaged under inert gas. Hygroscopic. After reconstitution, prepare aliquots and store at -20°C.
 
480-094
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480-094

Product Literature References

A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage: S. Vispe, et al.; PNAS 97, 9886 (2000), Abstract; Full Text
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 4332 (1995), Abstract;
Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 389 (1995), Abstract;

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