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8-Hydroxyguanine

 
ALX-480-091-M010 10 mg 35.00 USD
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Oxidative DNA degradation product.

Product Specification

Alternative Name:8-Oxoguanine, 7,8-Dihydro-8-oxoguanine, 8-oxoG
 
Formula:C5H5N5O2
 
MW:167.1
 
CAS:5614-64-2
 
Purity:≥90% (HPLC (UV))
 
Appearance:White to off-white powder.
 
Solubility:Soluble in conc. sodium hydroxide. May be further diluted and neutralized with water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ALX-480-091
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ALX-480-091

Product Literature References

Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1: J.W. Hyun, et al.; Oncogene 19, 4476 (2000), Abstract;
Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg DNA repair enzyme: N.Y. Tretyakova, et al.; Chem. Res. Toxicol. 13, 658 (2000), Abstract;
8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage: H.J. Helbock, et al.; Meth. Enzymol. 300, 156 (1999), Abstract;
Oxidative denitrification of the antitumour drug hydroxyguanidine: S.A. Everett, et al.; Free Radic. Biol. Med. 24, 1 (1998), Abstract;
DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions: T.H. Zastawny, et al.; Free Radic. Biol. Med. 18, 1013 (1995), Abstract;
DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells: J.P. Spencer, et al.; FEBS Lett. 374, 233 (1995), Abstract;
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection: M.K. Shigenaga, et al.; Meth. Enzymol. 234, 16 (1994), Abstract;
Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer: P. Jaruga, et al.; FEBS Lett. 341, 59 (1994), Abstract;

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