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8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate . sodium salt

Activator of PKG and CNG channels
 
ALX-480-088-M001 1 mg 38.00 USD
 
ALX-480-088-M005 5 mg 145.00 USD
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Selective activator of cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.

Product Specification

Alternative Name:8-pCPT-cGMP . Na
 
Formula:C16H14ClN5O7PS . Na
 
MW:486.8 . 23.0
 
CAS:51239-26-0
 
Purity:≥99% (HPLC)
 
Identity:Determined by ESI-MS and UV/VIS.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ALX-480-088
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ALX-480-088

Product Literature References

Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992), Abstract;
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger, et al.; PNAS 89, 1031 (1992), Abstract;

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