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8-Hydroxyguanosine

 
ALX-480-075-M005 5 mg 106.00 USD
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Oxidized form of the nucleoside guanosine. Formed in vivo by the free radical oxidation of RNA molecules, with subsequent degradation and cleavage of the nucleic acid.

Product Specification

Alternative Name:8-OHG
 
Formula:C10H13N5O6
 
MW:299.2
 
CAS:3868-31-3
 
Purity:≥98% (HPLC)
 
Identity:Determined by UV-VIS and ESI-MS.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in conc. NaOH. Once solubilized it can be further diluted and neutralized with water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ALX-480-075
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ALX-480-075

Product Literature References

Guanosine and its modified derivatives are endogenous ligands for TLR7: T. Shibata, et al.; Int. Immunol. 28, 211 (2016), Abstract;
Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes: M. Lodovici, et al.; Free Radic. Biol. Med. 28, 13 (2000), Abstract;
Involvement of oxidative stress in motorcycle exhaust particle-induced DNA damage and inhibition of intercellular communication: M.L. Kuo, et al.; Mutat. Res. 413, 143 (1998), Abstract;
Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool: J.Y. Mo, et al.; PNAS 89, 11021 (1992), Abstract;
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem. 28, 1194 (1985), Abstract;

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