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Guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt

PKG inhibitor



ALX-480-072-M001	1 mg	247.00 USD
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Inhibitor of cGMP-dependent protein kinase (PKG) 1α (cGMP antagonist). Resistant against mammalian cyclic nucleotid-dependent phosphodiesterases. No metabolic side effects. Low membrane permeability.

Product Details

Alternative Name:	Rp-cGMPS . Na, cGMPS . Na, Rp-Isomer

Formula:	C₁₀H₁₁N₅O₆SP . Na

MW:	360.3 . 23.0

CAS:	86562-09-6

Purity:	≥98% (HPLC)

Appearance:	White to off-white solid.

Solubility:	Soluble in water (125mM), DMSO (2mM), DMF (1mM), methanol (7mM) or PBS, pH 7.4 (125mM).

Shipping:	Blue Ice

Long Term Storage:	-20°C

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Nitric oxide mediates activity-dependent change to synaptic excitation during a critical period in Drosophila: C.N.G. Giachello, et al.; Sci. Rep. 11, 20286 (2021), Abstract;

Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS: E. Butt, et al.; Br. J. Pharmacol. 116, 3110 (1995), Abstract;

Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990), Abstract;