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Guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt

PKG inhibitor
 
ALX-480-072-M001 1 mg 183.00 USD
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Inhibitor of cGMP-dependent protein kinase (PKG) 1α (cGMP antagonist). Resistant against mammalian cyclic nucleotid-dependent phosphodiesterases. No metabolic side effects. Low membrane permeability.

Product Specification

Alternative Name:Rp-cGMPS . Na, cGMPS . Na, Rp-Isomer
 
Formula:C10H11N5O6SP . Na
 
MW:360.3 . 23.0
 
CAS:86562-09-6
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (125mM), DMSO (2mM), DMF (1mM), methanol (7mM) or PBS, pH 7.4 (125mM).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-480-072
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ALX-480-072

Product Literature References

Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS: E. Butt, et al.; Br. J. Pharmacol. 116, 3110 (1995), Abstract;
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990), Abstract;

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