Replaces Prod. #: BML-G305
- Used to obtain crystal structures of GTPases and measure their stability in presence of ligands
Guanosine 5’-O-(3-thiotriphosphate) (GTP-g-S) is a non-hydrolyzable analog of guanosine 5’-O-triphosphate (GTP) (Prod. No. ALX-480-057). GTP-g-S stimulates inositol trisphosphate formation in membranes.
Product Details
| Alternative Name: | GTP-γ-S . 4Li |
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| Formula: | C10H12N5O13P3S . 4Li |
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| MW: | 535.2 . 27.8 |
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| CAS: | 94825-44-2 |
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| Purity: | ≥85% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A functional role for GTP-binding proteins in synaptic vesicle cycling: S.D. Hess, et al.; Science
259, 1169 (1993),
Abstract;
G proteins: transducers of receptor-generated signals: A.G. Gilman; Ann. Rev. Biochem.
56, 615 (1987),
Abstract;
Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C: S. Orellana, et al.; J. Biol. Chem.
262, 1638 (1987),
Abstract;
Full Text
General Literature References
Small conductance chloride channels in acinar cells from the rat mandibular salivary gland are directly controlled by a G-protein: D.K. Martin; Biochem. Biophys. Res. Commun.
192, 1266 (1993),
Abstract;
Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes: S.T. Silk, et al.; J. Biol. Chem.
264, 21466 (1989),
Abstract;
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