O⁶-Benzylguanine

DNA alkyltransferase substrate and inhibitor



ALX-480-019-M010	10 mg	42.00 USD

ALX-480-019-M050	50 mg	165.00 USD

Effective substrate and efficient inactivator of DNA alkyltransferase.

Product Specification

Identity:	Identity determined by ¹H-NMR.

Formula:	C₁₂H₁₁N₅O

MW:	241.2

Purity:	≥98% (TLC)

Appearance:	White to off-white powder.

CAS:	19916-73-5

Solubility:	Soluble in methanol (20mg/ml).

Long Term Storage:	+20°C

Hazard:	IRRITANT.

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Product Literature References

Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo: E.L. Kreklau, et al.; Pharmacol. Exp. Ther. 291, 1269 (1999), Abstract;

O6-benzylguanine and its role in chemotherapy: M.E. Dolan & A.E. Pegg; Cancer Res. 3, 837 (1997), Abstract;

Activation of human O6-alkylguanine-DNA alkyltransferase by DNA: K. Goodtzova, et al.; Biochemistry 33, 8385 (1994), Abstract;

Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine: R.H. Elder, et al.; Biochem. J. 298, 231 (1994), Abstract;