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Menadione

IDO inhibitor
 
ALX-460-007-G010 10 g 35.00 USD
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Cytotoxic in various cell lines. Induces apoptosis via elevation of peroxide and superoxide radical levels. Affects gap-junctional intercellular communication by mediation of tyrosine phosphorylation.Inhibitor of indoleamine 2,3-dioxygenase (IDO) with an IC50 of ~1µM.

Product Specification

Alternative Name:Vitamin K3, 2-Methyl-1,4-naphthoquinone
 
Formula:C11H8O2
 
MW:172.2
 
CAS:58-27-5
 
MI:14: 5831
 
RTECS:QL9100000
 
Purity:≥98% (HPLC)
 
Appearance:Off-white to yellow crystalline solid.
 
Solubility:Soluble in 96% ethanol (16mg/ml) or DMSO (1mg/ml); almost insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light.
 
460-007
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460-007

Product Literature References

Flow cytometric evaluation of sperm superoxide anion production in rats with experimental varicocele: A. Jafari, et al.; Urology 75, 217 (2010), Abstract;
Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors: S. Kumar, et al.; J. Med. Chem. 51, 1706 (2008), Abstract;
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells: D.N. Criddle, et al.; J. Biol. Chem. 281, 40485 (2006), Abstract; Full Text
Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy: J. Mauzeroll, et al.; PNAS 101, 17582 (2004), Abstract; Full Text
2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade: L.O. Klotz, et al.; Cancer Res. 62, 4922 (2002), Abstract; Full Text
Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines: H. Okayasu, et al.; Anticancer Res. 21, 2387 (2001), Abstract;
Apoptosis-inducing activity of vitamin C and vitamin K: H. Sakagami, et al.; Cell Mol. Biol. 46, 129 (2000), Abstract;
Cytotoxic effect through fas/APO-1 expression due to vitamin K in human glioma cells: L.K. Sun, et al.; J. Neurooncol. 47, 31 (2000), Abstract;
Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase: F.Y. Wu and T.P.; Eur. J. Cancer 35, 1388 (1999), Abstract;

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