Macrotetrolide antibiotic. Monovalent cation ionophore with high selectivity for ammonium and potassium. Specifically inhibits the processing of cytoplasmic precursor proteins destined for the mitochondria. Inhibits the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in multidrug resistant (MDR) cancer cells.
Product Details
| Alternative Name: | Polynactin, Werramycin A |
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| Formula: | C40H64O12 |
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| MW: | 736.9 |
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| Source: | Isolated from Streptomyces griseus. |
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| CAS: | 6833-84-7 |
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| MI: | 14: 6675 |
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| RTECS: | RH1685000 |
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| Purity: | ≥98% (TLC) (Total homologs) |
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| Purity Detail: | Mixture of two homologs (~80% nonactin and ~20% monactin) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in DMSO (10mg/ml), dichloromethane (10mg/ml), methanol, 100% ethanol; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A new potentiometric ammonium electrode for biosensor construction: E. Karakus, et al.; Artif. Cells. Blood Substit. Immobil. Biotechnol.
34, 523 (2006),
Abstract;
Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane: C.A. Garcia, et al.; J. Pharm. Biomed. Anal.
31, 11 (2003),
Abstract;
Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effects of ionophores on 4’-O-tetrahydropyranyl-adriamycin incorporation in K562 drug-resistant cells : M.N. Borrel, et al.; Eur. J. Biochem.
223, 125 (1994),
Abstract;
Antibiotics as tools for metabolic studies. V. Effect of nonactin, monactin, dinactin, and trinactin on oxidative phosphorylation and adenosine triphosphatase induction: S.N. Graven, et al.; Biochemistry
5, 1729 (1966),
Abstract;
Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin: S.N. Graven, et al.; Biochemistry
5, 1735 (1966),
Abstract;
The in vitro activity of nonactin and Its homologs: Monactin, dinactin and trinactin: E. Meyers, et al.; J. Antibiot.
18, 128 (1965),
Abstract;
[Antibacterial spectrum of nonactin with special consideration of Corynebacteriaceae]: W. Kohler, et al.; Zentralbl Bakteriol [Orig]
194, 457 (1964),
Abstract;
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