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Sapintoxin D (high purity)

PKC ligand
 
ALX-445-047-M001 1 mg 65.00 USD
 
ALX-445-047-M005 5 mg 197.00 USD
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Fluorescent, highly potent phorbol ester. Useful for membrane studies.

Product Specification

Alternative Name:Phorbol 12-N-methylanthranilate
 
Formula:C30H37NO8
 
MW:539.6
 
CAS:80998-07-8
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in methanol, DMSO or chloroform.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
ALX-445-047
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ALX-445-047

Product Literature References

Phorbol esters: structure, biological activity, and toxicity in animals: G. Goel, et al.; Int. J. Toxicol. 26, 279 (2007), Abstract;
Conformation of the C1 phorbol-ester-binding domain participates in the activating conformational change of protein kinase C: C. Ho, et al.; Biochem. J. 344, 451 (1999), Abstract; Full Text
Sapintoxin D is a weak tumour promoter in Sencar mouse skin: J.R. McLean, et al.; J. Pharm. Pharmacol. 47, 263 (1995), Abstract;
Effects of five phorbol esters on gap junctional intercellular communication, morphological transformation and epidermal growth factor binding in Syrian hamster embryo cells: T. Husoy, et al.; Carcinogenesis 14, 73 (1993), Abstract;
Effects of biologically active tumour-promoting and non-promoting phorbol esters on in vitro growth of melanocytic cells: G. Brooks, et al.; Pigment Cell. Res. 3, 98 (1990), Abstract;
Fluorescent phorbol ester binding to the receptor protein kinase c in-vitro and in-vivo: N.A. Morrice, et al.; J. Pharm. Pharmacol. 38, 30P (1986), Abstract;
Sapintoxin D, A New Phorbol Ester From Sapium indicum: S.E. Taylor, et al.; J. Nat. Prod. 44, 729 (1981), Abstract;

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