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Methotrexate

Dihydrofolate reductase inhibitor
 
ALX-440-045-M050 50 mg 44.00 USD
 
ALX-440-045-M100 100 mg 85.00 USD
 
ALX-440-045-M500 500 mg 210.00 USD
 
ALX-440-045-G001 1 g 299.00 USD
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Replaces Prod. #: BML-CC103

Folic acid antagonist. Potent inhibitor of dihydrofolate reductase. Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.

Product Specification

Alternative Name:(+)-Amethopterin, 4-Amino-10-methylfolic acid, Methylaminopterin, MTX
 
Formula:C20H22N8O5
 
MW:454.5
 
CAS:59-05-2
 
MI:14: 5985
 
Purity:≥98% (HPLC)
 
Appearance:Yellow powder.
 
Solubility:Soluble in alkaline solution; insoluble in water, 100% ethanol or ether.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
ALX-440-045
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ALX-440-045

Product Literature References

Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis: M. Cutolo, et al.; J. Rheumatol. 27, 2551 (2000), Abstract;
Mechanisms of action of methotrexate: L. Genestier, et al.; Immunopharmacology 47, 247 (2000), Abstract;
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?: L.D. Fairbanks, et al.; Biochem. J. 342, 143 (1999), Abstract;
Activation-dependent lymphocyte apoptosis induced by methotrexate: R. Paillot, et al.; Transplant. Proc. 30, 2348 (1998), Abstract;
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells: L. Genestier, et al.; J. Clin. Invest. 102, 322 (1998), Abstract;
Methotrexate induces apoptotic cell death in human keratinocytes: M. Heenen, et al.; Arch. Dermatol. Res. 290, 240 (1998), Abstract;
Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro: L.I. Huschtscha, et al.; Br. J. Cancer. 73, 54 (1996), Abstract;
Cell-cycle-stage specificity of the methotrexate block as resolved by X-ray-induced chromosome damage: V.B. Richardson, et al.; Cytogenet. Cell. Genet. 66, 126 (1994), Abstract;
Polymerization of tubulin in apoptotic cells is not cell cycle dependent: S.M. Pittman, et al.; Exp. Cell. Res. 215, 263 (1994), Abstract;

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