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(6R)-5,6,7,8-Tetrahydro-L-biopterin . dihydrochloride

NOS cofactor
ALX-440-001-M005 5 mg 33.00 USD
ALX-440-001-M025 25 mg 85.00 USD
ALX-440-001-M100 100 mg 211.00 USD
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Replaces Prod. #: BML-CN250

Cofactor of nitric oxide synthases (NOS).

Product Specification

Alternative Name:(6R)-BH4 . 2HCl, [6R-[6R*(1R*,2S*)]]-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone . 2HCl, Sapropterin . dihydrochloride
Formula:C9H15N5O3 . 2HCl
MI:14: 8368
Purity:≥98% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in water (25mg/ml).
Long Term Storage:-20°C
Use/Stability:Stable for several years when stored at -20°C.
Sensitive to oxidation, especially in neutral and alkaline solutions. Solutions must be stored at -20°C or colder immediately after preparation. Use oxygen free water with the lowest possible pH. Ascorbic acid, DTT, or other antioxidants may be added in order to increase stability.
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Product Literature References

Protective effects of (6R) 5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion induced suppression of reactive hyperemia in rat gingiva: Y. Tanaka, et al. ; J. Clin. Biochem. Nutr. 58, 69 (2015), Abstract; Full Text
Availability of tetrahydrobiopterin is not a factor in the inability to detect nitric oxide production by human macrophages: N. Sakai and S. Milstien; BBRC 193, 378 (1993), Abstract;
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP: G. Werner-Felmayer, et al.; J. Biol. Chem. 268, 1842 (1993), Abstract; Full Text
Regulation of the L-arginine-dependent and tetrahydrobiopterin- dependent biosynthesis of nitric oxide in murine macrophages: G. Schoedon, et al.; Eur. J. Biochem. 213, 833 (1993), Abstract;
Tetrahydrobiopterin and cytokines: E.R. Werner, et al.; Proc. Soc. Exp. Biol. Med. 203, 1 (1993), (Review), Abstract;
Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity: J.M. Hevel & M.A. Marletta; Biochemistry 31, 7160 (1992), Abstract;
Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages: R.A. Pufahl, et al.; Biochemistry 31, 6822 (1992), Abstract;
Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor: P. Klatt, et al.; FEBS Lett. 305, 160 (1992), Abstract;
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine- induced nitric oxide generation by vascular smooth muscle: S.S. Gross & R. Levi; J. Biol. Chem. 267, 25722 (1992), Abstract; Full Text
Brain nitric oxide synthase is a biopterin- and flavin-containing multi- functional oxido-reductase: B. Mayer, et al.; FEBS Lett. 288, 187 (1991), Abstract;
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells: J.S. Pollock, et al.; PNAS 88, 10480 (1991), Abstract;
Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine: J. Giovanelli, et al.; PNAS 88, 7091 (1991), Abstract;
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages: N.S. Kwon et al.; J. Biol. Chem. 264, 20496 (1989), Abstract;

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