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Necrostatin-5

Necroptosis inhibitor
 
ALX-430-169-M005 5 mg 48.00 USD
 
ALX-430-169-M025 25 mg 192.00 USD
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Necroptosis inhibitor. In contrary to the mechanism of necrostatin-1 (Prod.No. BML-AP309) it was shown that necrostatin-5 inhibits RIP1 kinase indirectly. A potent inhibitor of immunoprecipitated, but not recombinant RIP1.

Product Specification

Alternative Name:Nec-5, 3-p-Methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide
 
Formula:C19H17N3O2S2
 
MW:383.5
 
CAS:337349-54-9
 
Purity:≥98% (HPLC, TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (>10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Scientific Background:The necrostatins inhibit non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. There are three different mechanisms: T-loop dependent inhibition by necrostatin-1, partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5.
 
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Product Literature References

Retinal pigment epithelial cell necroptosis in response to sodium iodate: J. Hanus, et al.; Cell Death Discov. 2, Article number 16054 (2016), Application(s): Cell culture, transfection, treatments, and MTT assay (human cells), Full Text
Idenfication of RIP1 kinase as a specific cellular target of necrostatins: A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008), Abstract;
Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5 : K. Wang, et al.; Bioorg. Med. Chem. Lett. 17, 1455 (2007), Abstract;

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Necrostatin-1 

Inhibits necroptosis
4311-88-0, ≥98% (TLC) | Print as PDF
 
BML-AP309-0020 20 mg 88.00 USD
 
BML-AP309-0100 100 mg 344.00 USD
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