Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Necrox-5™ . methanesulfonate

Necrosis inhibitor
ALX-430-167-M001 1 mg 119.00 USD
ALX-430-167-M005 5 mg 360.00 USD
Do you need bulk/larger quantities?
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1μM NecroX™-5 prevented ~50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.

Product Specification

Alternative Name:[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine
Formula:C25H31N3O3S . 2 CH4O3S
MW:453.6 . 192.2
Purity:≥95% (HPLC)
Appearance:Light green.
Solubility:Soluble in DMSO (>10mg/ml) or distilled water (>10mg/ml).
To aid in dissolution lower the pH to 2-3. This can be accomplished by using 2-3 drops of MSA (methanesulfonic acid). Alternatively use HCl combined with 15-20% HPCD.
Application Notes:Can be used for in vitro and in vivo applications.
For in vitro experiments, dissolve Necrox-5™ in DMSO to 20-50mM stock solution and dilute further in cell culture media. Treat cells with 30μM to 0.1μM final concentration.
For in vivo experiments, dissolve the product in distilled water to 10mg/ml stock solution. Further dilutions should be made in distilled water. Do not use PBS!
Optimal conditions must be determined individually for each application.
Long Term Storage:-20°C
Handling:Protect from light.
Please mouse over

Product Literature References

Necrotic cell death in atherosclerosis: W. Martinet, et al.; Basic Res. Cardiol. 106, 749 (2011), Abstract;
NecroX as a novel class of mitochondrial reactive oxygen species and ONOO(-) scavenger: H.J. Kim, et al.; Arch. Pharm. Res. 33, 1813 (2010), Abstract;

Related Products


Necrosis inhibitor
≥95% (NMR, LCMS) | Print as PDF
ALX-430-166-M001 1 mg 137.00 USD
ALX-430-166-M005 5 mg 472.00 USD
Do you need bulk/larger quantities?

Product Toolbox


Certificate of Analysis


By catalog section:


Technical Service
Customer Service

Related Literature

Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

Product Flyers
Necrosis & Necroptosis Inhibitors
Necrosis & Necroptosis Inhibitors
Download as PDF

All new literature pieces

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,