Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1μM NecroX™-5 prevented ~50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.
Product Details
| Alternative Name: | [5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine |
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| Formula: | C25H31N3O3S . 2 CH4O3S |
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| MW: | 645.8 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Off-white to light pink solid. |
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| Solubility: | Soluble in DMSO.
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Necrocide 1 Mediates a Non-Apoptotic Necrotic Cell Death and Immunogenic Response in Human Cancer Cells: J. Zhang, et al.; Cell Death Dis.
14, 238 (2023),
Abstract;
Down-regulation of intracellular reactive oxygen species attenuates P-glycoprotein-associated chemoresistance in Epstein-Barr virus-positive NK/T-cell lymphoma: Y.S. Nam, et al.; Am. J. Transl. Res.
11, 1359 (2019),
Abstract;
Necrotic cell death in atherosclerosis: W. Martinet, et al.; Basic Res. Cardiol.
106, 749 (2011),
Abstract;
NecroX as a novel class of mitochondrial reactive oxygen species and ONOO(-) scavenger: H.J. Kim, et al.; Arch. Pharm. Res.
33, 1813 (2010),
Abstract;
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