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Lamotrigine

Na+ channel blocker
 
ALX-430-160-M025 25 mg 161.00 USD
 
ALX-430-160-M100 100 mg 453.00 USD
 
ALX-430-160-M500 500 mg 1,534.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-NA137

Lamotrigine blocks voltage-gated sodium channels. Inhibits the release of glutamate. Neuroprotective. Anticonvulsant.

Product Specification

Alternative Name:6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine, LTG, BW-430C
 
Formula:C9H7Cl2N5
 
MW:256.1
 
CAS:84057-84-1
 
MI:14: 5353
 
RTECS:XY5850700
 
Purity:≥98% (Assay)
 
Identity:Determined by IR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO (60°C, 20mg/ml) or dimethyl formamide; slightly soluble in anhydrous ethanol or dilute hydrochloric acid; almost insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
430-160
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430-160

Product Literature References

Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy: C. Luna-Tortos, et al.; Neuropharmacology 58, 1019 (2010), Abstract;
Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy: G. Papazisis, et al.; Int. J. Neuropsychopharmacol. 11, 321 (2008), Abstract;
Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice: E. Lagrue, et al.; Pediatr. Res. 62, 14 (2007), Abstract;
A novel drug binding site on voltage-gated sodium channels in rat brain: D.R. Ridall, et al.; Mol. Pharmacol. 69, 278 (2006), Abstract; Full Text
Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders: S. Malik, et al.; Expert Rev. Neurother. 6, 1609 (2006), Abstract;
Lamotrigine in the treatment of bipolar disorder: Z. Bhagwagar & G.M. Goodwin; Expert Opin. Phamacother. 6, 1401 (2005), Abstract;
Review of lamotrigine and its clinical applications in epilepsy: H. Choi & M.J. Morrell; Expert Opin. Pharmacother. 4, 243 (2003), Abstract;
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception: T.M. Laughlin, et al.; J. Pharmacol. Exp. Ther. 302, 1168 (2002), Abstract; Full Text
A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group: J.R. Calabrese, et al.; J. Clin. Psychiatry 60, 79 (1999), Abstract;
Cellular and molecular actions of lamotrigine: Possible mechanisms of efficacy in bipolar disorder: X. Xie & R.M. Hagan; Neuropsychobiology 38, 119 (1998), Abstract;
Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans: A.F. Cohen, et al.; Clin. Pharmacol. Ther. 42, 535 (1987), Abstract;
Acute effects of lamotrigine (BW430C) in persons with epilepsy: C.D. Binnie, et al.; Epilepsia 27, 248 (1986), Abstract;
Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and rats: A.A. Miller, et al.; Epilepsia 27, 483 (1986), Abstract;
Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action: M.J. Leach, et al.; Epilepsia 27, 490 (1986), Abstract;
The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy: S. Jawad, et al.; Br. J. Clin. Pharmacol. 22, 191 (1986), Abstract; Full Text
Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam: A.F. Cohen, et al.; Br. J. Clin. Pharmacol. 20, 619 (1985), Abstract; Full Text

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