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4EGI-1

eIF inhibitor
 
ALX-430-155-M002 2 mg 223.00 USD
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Selective and cell permeable inhibitor of the interaction between the human eukaryotic translation initiation factors 4E (eIF4E) and 4G (eIF4G).

Product Specification

Alternative Name:α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
 
Formula:C18H12Cl2N4O4S
 
MW:451.3
 
CAS:315706-13-9
 
Purity:≥95%
 
Identity:Determined by MS, 1H- and 13C-NMR.
 
Appearance:Brown solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
430-155
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430-155

Product Literature References

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR: S. Ivanov & C. Roy; Nat. Immunol. 14, 1219 (2013), Application(s): Analysis of mouse macrophages by WB, PCR, Abstract; Full Text
Spinal protein kinase M zeta underlies the maintenance mechanism of persistent nociceptive sensitization: M.N. Asiedu, et al.; J. Neurosci. 31, 6646 (2011), Abstract; Full Text
BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis: F. Grespi, et al.; Cell Death Differ. 17, 1672 (2010), Abstract; Full Text
IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex: O.K. Melemedjian, et al.; J. Neurosci. 30, 15113 (2010), Abstract; Full Text
The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation: S. Fan, et al.; Neoplasia 12, 346 (2010), Abstract;
Uncoupling stress granule assembly and translation initiation inhibition: S. Mokas, et al.; Mol. Biol. Cell 20, 2673 (2009), Abstract; Full Text
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G: N.J. Moerke, et al.; Cell 128, 257 (2007), Abstract;

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