Cannabidiol

Anticonvulsive and neuroprotective



ALX-430-152-M005	5 mg	NOT SOLD

ALX-430-152-M001	1 mg	NOT SOLD

Non-psychotropic, anticonvulsive and neuroprotective in vivo. Shown to be a weak CB₁ receptor antagonist and inhibitor of anandamide uptake (IC₅₀=3.35mM and 27.5mM, respectively). Weak agonist of TRPV1 (EC₅₀=3.5mM).

Product Specification

Alternative Name:	CBD, 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol

Formula:	C₂₁H₃₀O₂

MW:	314.5

Purity:	≥98% (HPLC)

Appearance:	White to pale yellow powder.

CAS:	13956-29-1

MI:	14: 1747

RTECS:	VH1600000

Source/Host:	Isolated from Cannabis sp.

Solubility:	Soluble in DMSO, 100% ethanol or methanol; insoluble in water.

Long Term Storage:	-20°C

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Product Literature References

Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells: E. Del Giudice, et al.; J. Leukoc. Biol. 81, 1512 (2007), Abstract; Full Text

Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression: E.J. Carrier, et al.; PNAS 103, 7895 (2006), Abstract; Full Text

Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines: P. Massi, et al.; J. Pharmacol. Exp. Ther. 308, 838 (2004), Abstract; Full Text

Effects of cannabidiol (CBD) on regional cerebral blood flow: J.A. Crippa, et al.; Neuropsychopharmacology 29, 417 (2004), Abstract; Full Text

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite: A.B. El-Remessy, et al.; Am. J. Pathol. 163, 1997 (2003), Abstract; Full Text

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis: A.M. Malfait, et al.; PNAS 97, 9561 (2000), Abstract; Full Text

Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants: A.J. Hampson, et al.; PNAS 95, 8268 (1998), Abstract; Full Text