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Mitochondria-targeted antioxidant
ALX-430-150-M005 5 mg 69.00 USD
Mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties, which may be used for both in vivo and in vitro experiments.

Product Specification

Alternative Name:(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride . monohydrate
Formula:C29H35N2O2ClP . H2O
MW:510.1 . 18.0
Purity:≥95% (TLC)
Identity:Determined by MS.
Appearance:Pink crystalline solid.
Solubility:Soluble in water, DMSO, 100% ethanol or methanol.
Long Term Storage:-20°C
Use/Stability:Solutions in water, saline, ethanol or DMSO are stable at +4°C for 1-2 weeks. DMSO stock solution can be stored also at -20°C.
Handling:Protect from light.
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Product Literature References

TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death Through a TRIF-Dependent Pathway: J. D. Schilling et al.; J. Immunol. 1285 (2013), Application(s): Inhibition of caspase in macrophages, Abstract; Full Text
Angiotensin II-induced production of mitochondrial ROS: Potential mechanisms and relevance for cardiovascular disease: Dikalov, S.I. & Nazarewicz, R.R.; Antioxid. Redox Signal. Epub ahead of print, (2012), Abstract;
Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel: M. Liu, et al.; Circ. Res. in press, (2010), Abstract;
SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery: H.L. Liang, et al.; Free Rad. Biol. Med. in press, (2010), Abstract;
Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res. 107, 106 (2010), Abstract;
Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells: H.L. Liang, et al.; Apoptosis 14, 1176 (2009), Abstract;

General Literature References

Targeting antioxidants to mitochondria by conjugation to lipophilic cations: M.P. Murphy & R.A. Smith; Annu. Rev. Pharmacol. Toxicol. 47, 629 (2007), Review, Abstract;

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