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Virstatin

 
ALX-430-147-M050 50 mg 137.00 USD
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Inhibits virulence regulation in V. cholerae. Prevents expression of cholera toxin and the toxin coregulated pilus (TCP) by inhibiting the transcriptional regulator ToxT. Effectively protects infant mice against TCP-dependent V. cholerae intestinal colonization in vivo. Displays little toxicity towards mammalian cells (up to 2mM for Hep2 cells).

Product Specification

Alternative Name:4-(N-(1,8-Naphthalimide))-n-butyric acid, 1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-butanoic acid
 
Formula:C16H13NO4
 
MW:283.3
 
CAS:88909-96-0
 
Purity:≥97% (HPLC)
 
Appearance:Off-white to yellow solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 6 months when stored at -20°C.
 
Handling:Protect from light.
 
430-147
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430-147

Product Literature References

Virstatin inhibits dimerization of the transcriptional activator ToxT: E. A. Shakhnovich, et al.; PNAS 104, 2372 (2007), Abstract;
Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization: D.T. Hung, et al.; Science 310, 670 (2005), Abstract;

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