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Locostatin

RKIP inhibitor
 
ALX-430-142-M005 5 mg 58.00 USD
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Cell permeable, potent inhibitor of interaction of Raf kinase inhibitor protein (RKIP) with Raf1 kinase. Blocks eukaryotic cell migration (IC50=14µM for inhibition of wound closure in MDCK cell monolayers). Inhibitor of early development in frog embryos and tissue dynamics in embryonic explants. Displays no antibacterial activity.

Product Specification

Alternative Name:UIC-1005, (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone, (4S)-3-[(E)-1-Oxo-2-butenyl]-4-(phenylmethyl)-2-oxazolidinone
 
Formula:C14H15NO3
 
MW:245.3
 
CAS:133812-16-5
 
Purity:≥95%
 
Identity:Identity determined by MS, 1H- and 13C-NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (10mg/ml) or methanol (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
430-142
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430-142

Product Literature References

The oxazolidinone derivative locostatin induces cytokine appeasement: A. Menoret, et al.; J. Immunol. 183, 7489 (2009), Abstract;
Sustained activation of Src-family tyrosine kinases by ischemia: A potential mechanism mediating extracellular signal-regulated kinase cascades in hippocampal dentate gyrus: J. Guo, et al.; Neuroscience 143, 827 (2006), Abstract;
A role for RKIP in cell motility: W.M. Bement; Chem. Biol. 12, 953 (2005), Abstract;
A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration: S. Zhu, et al.; Chem. Biol. 12, 981 (2005), Abstract;
A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration: K.T. Mc Henry, et al.; ChemBioChem 3, 1105 (2002), Abstract;

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