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F16

 
ALX-430-140-M005 5 mg 31.00 USD
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Cell permeable, fluorogenic, delocalized lipophilic mitochondrial toxin. Induces apoptosis as well as necrosis in tumor cells.

Product Specification

Alternative Name:4-[(E)-2-(Indol-3-yl)ethenyl]-N-methylpyridinium iodide
 
Formula:C16H15IN2
 
MW:362.2
 
CAS:36098-33-6
 
Purity:≥98% (HPLC)
 
Appearance:Orange solid.
 
Solubility:Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS, pH 7.2.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for 2 years after receipt when stored at -20°C. Organic stock solutions are stable for at least 6 months when stored at -20°C. We do not recommend storing the aqueous solutions for more than one day.
 
Handling:Protect from light. Hygroscopic.
 
430-140
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430-140

Product Literature References

A predictive model for the selective accumulation of chemicals in tumor cells: S. Trapp and R.W. Horobin; Eur. Biophys. J. 34, 959 (2005), Abstract;
F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell: V.R. Fantin and P. Leder; Cancer Res. 64, 329 (2004), Abstract;
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth: V.R. Fantin, et al.; Cancer Cell 2, 29 (2002), Abstract;

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