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Irinotecan . hydrochloride . trihydrate

Topoisomerase I inhibitor
 
ALX-430-139-M005 5 mg 99.00 USD
 
ALX-430-139-M025 25 mg 378.00 USD
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A member of the camptothecin drug family, and an inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication topoisomerase I mediates the relaxation of super coiled DNA, and its inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is, therefore, an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.

Product Specification

Alternative Name:Camptosar, 7-ethyl-10-hydroxycamptothecin, CPT-11
 
Formula:C33H38N4O6 . HCl . 3H2O
 
MW:586.7 . 36.5 . 54.0
 
CAS:136572-09-3
 
MI:14: 5091
 
RTECS:DW1061000
 
Purity:≥97% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White solid.
 
Solubility:Slightly soluble in methanol or water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
430-139
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430-139

Product Literature References

Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis: Y. Takeba, et al.; J. Pharmacol. Sci. 104, 232 (2007), Abstract;
Human DNA-Topoisomerases - Diagnostic and Therapeutic Implications for Cancer: U. Kellner, et al.; Onkologie 23, 424 (2000), Abstract;
Therapeutic advances in small cell lung cancer: F.P. Worden and G.P. Kalemkerian; Expert Opin. Investig. Drugs 9, 565 (2000), Abstract;
The role of irinotecan in colorectal cancer: L.B. Saltz; Curr. Oncol. Rep. 1, 155 (1999), Abstract;
Induction of tumor necrosis factor by a camptothecin derivative, irinotecan, in mice and human mononuclear cells: S. Goto, et al.; Anticancer Res. 16, 2507 (1996), Abstract;

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