Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

IM-54

Necrosis inhibitor
 
ALX-430-137-M001 1 mg 34.00 USD
 
ALX-430-137-M005 5 mg 145.00 USD
 
ALX-430-137-M025 25 mg 455.00 USD
Do you need bulk/larger quantities?
 
Cell permeable inhibitor of necrosis. Selectively blocks oxidative stress-induced necrotic cell death (~3µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100µM H2O2). Does not protect against etoposide-induced apoptosis or display antioxidant properties. Does not affect S6K1 and PKC kinase activities at concentrations of 50µM.

Product Specification

Alternative Name:2-(1H-Indol-3-yl)-3-pentylamino-maleimide
 
Formula:C19H23N3O2
 
MW:325.4
 
CAS:861891-50-1
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO (100mg/ml), dichloromethane, 100% ethanol or methanol (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
430-137
Please mouse over
430-137

Product Literature References

Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives: K. Dodo, et al.; Bioorg. Med. Chem. Lett. 15, 3114 (2005), Abstract;

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Brochures
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

Product Flyers
Necrosis & Necroptosis Inhibitors
Necrosis & Necroptosis Inhibitors
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,