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HQNO

NADH inhibitor
 
ALX-430-130-M010 10 mg 111.00 USD
 
ALX-430-130-M050 50 mg 434.00 USD
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Naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. Inhibits NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR).

Product Specification

Alternative Name:2-n-Heptyl-4-hydroxyquinoline N-oxide
 
Formula:C16H21NO2
 
MW:259.3
 
Source:Synthetic.
 
CAS:341-88-8
 
MI:14: 4751
 
RTECS:VC5890000
 
Purity:≥99% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in 100% ethanol, DMSO or chloroform; very slightly soluble in water, pH>7.0.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from light. Hygroscopic.
 
alx-430-130
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Product Literature References

Creation of a gold nanoparticle based electrochemical assay for the detection of inhibitors of bacterial cytochrome bd oxidases: E. Fournier, et al. ; Bioelectrochemistry 111, 109 (2016), Application(s): Inhibition, Abstract;
Physiological roles of three Na+/H+ antiporters in the halophilic bacterium Vibrio parahaemolyticus: T. Kuroda, et al.; Microbiol. Immunol. 49, 711 (2005), Abstract;
Purification and characterization of succinate:menaquinone oxidoreductase from Corynebacterium glutamicum: T. Kurokawa and J. Sakamoto; Arch. Microbiol. 183, 317 (2005), Abstract;
Quinone reduction by Rhodothermus marinus succinate:menaquinone oxidoreductase is not stimulated by the membrane potential: A.S. Fernandes, et al.; BBRC 330, 565 (2005), Abstract;
Enzymatic properties of the membrane-bound NADH oxidase system in the aerobic respiratory chain of Bacillus cereus: M.S. Kim & Y.J. Kim; J. Biochem. Mol. Biol. 37, 753 (2004), Abstract;
Involvement of sulfide:quinone oxidoreductase in sulfur oxidation of an acidophilic iron-oxidizing bacterium, Acidithiobacillus ferrooxidans NASF-1: S. Wakai, et al.; Biosci. Biotechnol. Biochem. 68, 2519 (2004), Abstract;
A stable isotope dilution assay for the quantification of the Pseudomonas quinolone signal in Pseudomonas aeruginosa cultures: F. Lepine, et al.; Biochim. Biophys. Acta 1622, 36 (2003), Abstract;
Sulfite-oxido-reductase is involved in the oxidation of sulfite in Desulfocapsa sulfoexigens during disproportionation of thiosulfate and elemental sulfur: T.M. Frederiksen & K. Finster; Biodegradation 14, 189 (2003), Abstract;
FTIR spectroscopic evidence for the involvement of an acidic residue in quinone binding in cytochrome bd from Escherichia coli: J. Zhang, et al.; Biochemistry 41, 4612 (2002), Abstract;
Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+ toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus: Y. Nakayama, et al.; Biol. Pharm. Bull. 22, 1064 (1999), Abstract;
Binding of HQNO to beef-heart sub-mitochondrial particles: G. Van Ark & J.A. Berden; Biochim. Biophys. Acta 459, 119 (1977), Abstract;
Structure of a naturally occurring antagonist of dihydrostreptomycin: J.W. Cornforth & A.T. James; Biochem. J. 63, 124 (1956), Abstract;
Inhibition of cytochrome system of heart muscle and of Staphylococcus aureus by 2-heptyl-4-hydroxyquinoline-N-oxide, an antagonist of dihydrostreptomycin: J.W. Lightbown & F.L. Jackson; Biochem. J. 58, 15 (1954), Abstract;

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