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Nutlin-3

Inhibitor of p53/MDM2 interaction
 
ALX-430-128-M001 1 mg 43.00 USD
 
ALX-430-128-M005 5 mg 187.00 USD
 
ALX-430-128-M025 25 mg 696.00 USD
Do you need bulk/larger quantities?
 
(+/-) -Nutlin-3 is an inhibitor of p53/MDM2 interaction (IC50=0.09µM).

Product Specification

Alternative Name:(±)-4-[4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-piperazin-2-one
 
Formula:C30H30Cl2N4O4
 
MW:581.5
 
CAS:548472-68-0
 
Purity:≥98% (HPLC (UV))
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in methanol, 100% ethanol, DMSO, dimethyl formamide or acetonitrile; sparingly soluble in a 1:10 solution of ethanol:PBS, pH 7.2.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least one year after receipt when stored at -20°C. We do not recommend storing the aqueous solution for more than one day.
 
430-128
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430-128

Product Literature References

Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation: M. Charni, et al.; Cell Death Differ. 23, 509 (2016), Application(s): Cell Culture, Abstract;
A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins: J. Soares, et al.; Pharmacol. Res. 95, 42 (2015), Application(s): Cell Culture, Abstract;
Whole-genome cartography of p53 response elements ranked on transactivation potential: T. Tebaldi, et al.; BMC Genomics 16, 464 (2015), Application(s): Cell Culture, Abstract; Full Text
A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity: B. Wawrzynow, et al.; J. Biol. Chem. 284, 11517 (2009), Abstract;
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas: G. Sarek, et al.; J. Clin. Invest. 117, 1019 (2007), Abstract; Full Text
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2: L.T. Vassilev, et al.; Science 303, 844 (2004), Abstract;

General Literature References

Drug discovery and p53: D.P. Lane, et al.; Drug Discov. Today 8, 347 (2003), Abstract;

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