(+/-) -Nutlin-3 is an inhibitor of p53/MDM2 interaction (IC50=0.09µM).
Product Details
| Alternative Name: | (±)-4-[4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-piperazin-2-one |
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| Formula: | C30H30Cl2N4O4 |
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| MW: | 581.5 |
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| CAS: | 548472-68-0 |
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| Purity: | ≥98% (HPLC (UV)) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in methanol, 100% ethanol, DMSO, dimethyl formamide or acetonitrile; sparingly soluble in a 1:10 solution of ethanol:PBS, pH 7.2. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least one year after receipt when stored at -20°C. We do not recommend storing the aqueous solution for more than one day. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation: M. Charni, et al.; Cell Death Differ.
23, 509 (2016),
Application(s): Cell Culture,
Abstract;
A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins: J. Soares, et al.; Pharmacol. Res.
95, 42 (2015),
Application(s): Cell Culture,
Abstract;
Whole-genome cartography of p53 response elements ranked on transactivation potential: T. Tebaldi, et al.; BMC Genomics
16, 464 (2015),
Application(s): Cell Culture,
Abstract;
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A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity: B. Wawrzynow, et al.; J. Biol. Chem.
284, 11517 (2009),
Abstract;
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas: G. Sarek, et al.; J. Clin. Invest.
117, 1019 (2007),
Abstract;
Full Text
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2: L.T. Vassilev, et al.; Science
303, 844 (2004),
Abstract;
General Literature References
Drug discovery and p53: D.P. Lane, et al.; Drug Discov. Today
8, 347 (2003),
Abstract;
