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KN-93 phosphate

CaM kinase II inhibitor
 
ALX-430-127-M001 1 mg 103.00 USD
 
ALX-430-127-M005 5 mg 350.00 USD
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Selective inhibitor of rat brain Ca2+/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A (PKA) activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.

Product Specification

Alternative Name:KN-93 (water soluble), 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine . hydrogen phosphate
 
Formula:C26H29ClN2O4S . H3PO4
 
MW:501.0 . 98.0
 
CAS:1188890-41-6
 
Purity:≥98% (1H-NMR)
 
Identity:Determined by NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO or water.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 2 years after receipt. Stock solutions are stable for up to 3 months when stored at -20°C.
 
Handling:Protect from light. Hygroscopic.
 
430-127
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Product Literature References

G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995), Abstract;
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993), Abstract;
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993), Abstract;
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991), Abstract;

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