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pH-sensitive nitroxide
ALX-430-120-M010 10 mg 42.00 USD
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pH-sensitive nitroxide for in vivo studies. The presence of two ionizable groups in the side-chains extends the range of pH sensitivity. The relatively high solubility in water and broad range of pH-sensitivity makes the probe particularly suitable for pH monitoring in stomach using non-invasive low-field EPR techniques.

Product Specification

Alternative Name:4-(Dimethylamino)-2-ethyl-5,5-dimethyl-2-pyridine-4-yl-2,5-dihydro-1H-imidazol-1-oxyl
Purity:≥99% (HPLC, EPR)
Appearance:Orange crystalline solid.
Solubility:Highly soluble in DMSO, methanol or 100% ethanol; moderately soluble in water.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
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Product Literature References

Real-time monitoring of drug-induced changes in the stomach acidity of living rats using improved pH-sensitive nitroxides and low-field EPR techniques: D.I. Potapenko, et al.; J. Magn. Reson. 182, 1 (2006), Abstract;
Nitroxides with two pK values--useful spin probes for pH monitoring within a broad range: I.A. Kirilyuk, et al.; Org. Biomol. Chem. 3, 1269 (2005), Abstract;
In vitro and in vivo measurement of pH and thiols by EPR-based techniques: V.V. Khramtsov, et al.; Antioxid. Redox Signal. 6, 667 (2004), Abstract;
Synthesis of the tetraethyl substituted pH-sensitive nitroxides of imidazole series with enhanced stability towards reduction: I.A. Kirilyuk, et al.; Org. Biomol. Chem. 2, 1025 (2004), Abstract;
Grignard reagent addition to 5-alkylamino-4H-imidazole 3-oxides: synthesis of new pH-sensitive spin probes : I.A. Kirilyuk, et al.; Synthesis 2003, 871 (2003), Abstract;

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