Beside DEPMPO (Prod. No. ALX-430-093), most efficient spin trap for the in vitro and in vivo detection of O-, N-, S-, and C-centered free radicals. Has a longer life-time than DMPO (Prod. No. ALX-430-090). More lipophilic (Kp=2.1) than DEPMPO.
Product Details
| Alternative Name: | 5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide |
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| Formula: | C11H22NO4P |
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| MW: | 263.3 |
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| Purity: | ≥98% (TLC, 1H- and 13C-NMR) |
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| Appearance: | Off-white to pale yellow low melting solid. |
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| Solubility: | Soluble in water, 100% ethanol or methylene chloride. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -80°C |
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| Handling: | Protect from light. Very hygroscopic. Handle under an inert atmosphere. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The Role of Chelating Agents and Amino Acids in Preventing Free Radical Formation in Bleaching Systems: J. Hodes, et al.; Free Radic. Biol. Med.
129, 194 (2018),
Abstract;
Study of natural anthraquinone colorants by EPR and UV/vis spectroscopy: Z. Machatova, et al.; Dyes Pigm. 132, 79 (2016), Application(s): Cell culture,
Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus: Y. Shi, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol.
304, R343 (2013),
Application(s): Electron paramagnetic resonance (EPR) spectroscopy,
Abstract;
Full Text
The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO : M. Culcasi, et al.; Free Radic. Biol. Med.
40, 1524 (2006),
Abstract;
5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties: F. Chalier & P. Tordo; J. C. S. Perkin Trans. II
2002, 2110 (2002),
Full Text
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