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ACP

Probe for oxidative stress detection
 
ALX-430-118-M010 10 mg 70.00 USD
 
ALX-430-118-M050 50 mg 234.00 USD
 
ALX-430-118-M250 250 mg 530.00 USD
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Cell permeable probe for the detection of intracellular oxidative stress. ACP can easily be deprotected with esterases to cyclic hydroxylamines, which are oxidized by ROS leading to ESR-detectable nitroxide radicals.

Product Specification

Alternative Name:1-Acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine
 
Formula:C11H20N2O3
 
MW:228.3
 
CAS:137052-08-5
 
Purity:≤0.05% paramagnetic impurities (by EPR)
 
Appearance:White to off-white crystalline powder.
 
Solubility:Soluble in water, methanol, 100% ethanol or DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
430-118
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430-118

Product Literature References

Pharmacokinetic study of acyl-protected hydroxylamine probe, 1-acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine, for in vivo measurements of reactive oxygen species: K. Saito, et al.; Free Radic. Biol. Med. 36, 517 (2004), Abstract;
Measurement of oxidative stress by EPR radical-probe technique: L. Valgimigli, et al.; Free Radical Biol. Med. 31, 708 (2001), (Review), Abstract;
In vivo EPR imaging by using an acyl-protected hydroxylamine to analyze intracerebral oxidative stress in rats after epileptic seizures: H. Yokoyama, et al.; Magn. Reson. Imaging 18, 875 (2000), Abstract;
Sensitive ESR determination of intracellular oxidative stress by using acyl-protected hydroxylamines as new spin reagents: O. Itoh, et al.; Chem. Lett. 29, 304 (2000), Abstract;

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