ACP

Probe for oxidative stress detection



ALX-430-118-M010	10 mg	67.00 USD

ALX-430-118-M050	50 mg	201.00 USD

ALX-430-118-M250	250 mg	505.00 USD

Cell permeable probe for the detection of intracellular oxidative stress. ACP can easily be deprotected with esterases to cyclic hydroxylamines, which are oxidized by ROS leading to ESR-detectable nitroxide radicals.

Product Specification

Alternative Name:	1-Acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine

Formula:	C₁₁H₂₀N₂O₃

MW:	228.3

Purity:	≤0.05% paramagnetic impurities (by EPR)

Appearance:	White to off-white crystalline powder.

Solubility:	Soluble in water, methanol, 100% ethanol or DMSO.

Long Term Storage:	-20°C

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Product Literature References

Pharmacokinetic study of acyl-protected hydroxylamine probe, 1-acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine, for in vivo measurements of reactive oxygen species: K. Saito, et al.; Free Radic. Biol. Med. 36, 517 (2004), Abstract;

Measurement of oxidative stress by EPR radical-probe technique: L. Valgimigli, et al.; Free Radical Biol. Med. 31, 708 (2001), (Review), Abstract;

In vivo EPR imaging by using an acyl-protected hydroxylamine to analyze intracerebral oxidative stress in rats after epileptic seizures: H. Yokoyama, et al.; Magn. Reson. Imaging 18, 875 (2000), Abstract;

Sensitive ESR determination of intracellular oxidative stress by using acyl-protected hydroxylamines as new spin reagents: O. Itoh, et al.; Chem. Lett. 304 (2000),