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HA14-1

Bcl-2 ligand
 
ALX-430-101-M005 5 mg 56.00 USD
 
ALX-430-101-M025 25 mg 217.00 USD
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Replaces Prod. #: BML-CM122

Cell permeable, low molecular weight Bcl-2 ligand. Antagonizes the function of Bcl-2 and induces apoptosis. In HL-60 cells, HA4-1 (50µM and 4h incubation) induced apoptosis of more than 90% of the cells. Apoptosis is blocked by ZVAD-FM. IC50 = ~9µM for competition with Flu-BakBH3 binding to Bcl-2.

Product Specification

Alternative Name:Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
 
Formula:C17H17BrN2O5
 
MW:409.2
 
CAS:65673-63-4
 
Purity:≥95% (1H-NMR)
 
Identity:Identity determined by IR, 1H-NMR.
 
Appearance:Off-white to light yellow powder.
 
Solubility:Soluble in DMSO (25mg/ml), dimethyl formamide or halogenated solvents; also soluble in 100% ethanol (25mg7ml, hot).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Unstable in solution. Prepare fresh solution for each application.
 
Handling:Keep cool and dry.
 
ALX-430-101
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ALX-430-101

Product Literature References

Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells: G. Qin, et al.; Exp. Cell Res. 336, 308 (2015), Application(s): Cell Culture, Abstract;
Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia: M. Milella, et al.; Blood 99, 3461 (2002), Abstract;
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001), Abstract;
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells: J.L. Wang, et al.; PNAS 97, 7124 (2000), Abstract;

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