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EMPO

Spin trapping reagent
 
ALX-430-098-M050 50 mg Inquire for pricing
 
ALX-430-098-M010 10 mg 82.00 USD
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Beside DEPMPO (Prod. No. ALX-430-093), most efficient spin trap for the in vitro and in vivo detection of O-, N-, S-, and C-centered free radicals. Has a longer life-time than DMPO (Prod. No. ALX-430-090).

Product Specification

Alternative Name:2-Ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide
 
Formula:C8H13NO3
 
MW:171.2
 
Purity:≥95% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Colorless to light yellow oil.
 
Solubility:Soluble in water, DMSO, ethanol or dichloromethane.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-80°C
 
Use/Stability:Store solutions at -20°C.
 
Handling:Protect from light. Hygroscopic.
 
430-098
EMPO Spectrum
Spectrum of the (O2-) – EMPO adduct.
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430-098 EMPO Spectrum

Product Literature References

EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines: S.I. Dikalov, et al.; Free Rad. Res. 45, 417 (2011), Abstract;
Measurement of reactive oxygen species in cardiovascular studies: S. Dikalov, et al.; Hypertension 49, 717 (2007), Abstract;
Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis: A.K. Doughan & S.I Dikalov; Antioxid. Redox Signal. 9, 1825 (2007), Abstract;
Indoxyl sulfate induces complex redox alterations in mesangial cells: A.K. Gelasco & J.R. Raymond; Am. J. Physiol. Renal Physiol. 290, F1551 (2006), Abstract;
Spin trapping of C- and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives: K. Stolze, et al.; Bioorg. Med. Chem. 14, 3368 (2006), Abstract;
The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO: M. Culcasi, et al.; Free Radic. Biol. Med. 40, 1524 (2006), Abstract;
Cytotoxicity of novel derivatives of the spin trap EMPO: N. Rohr-Udilova, et al.; Bioorg. Med. Chem. Lett. 16, 541 (2005), Abstract;
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005), Abstract;
Spin adduct formation from lipophilic EMPO-derived spin traps with various oxygen- and carbon-centered radicals: K. Stolze, et al.; Biochem. Pharmacol. 69, 297 (2005), Abstract;
Spin trapping of superoxide by diester-nitrones: A. Allouch, et al.; Org. Biomol. Chem. 3, 2458 (2005), Abstract; Full Text
A new kinetic approach to the evaluation of rate constants for the spin trapping of superoxide/hydroperoxyl radical by nitrones in aqueous media: R. Lauricella, et al.; Org. Biomol. Chem. 2, 1304 (2004), Abstract;
Kinetic study and theoretical analysis of hydroxyl radical trapping and spin adduct decay of alkoxycarbonyl and dialkoxyphosphoryl nitrones in aqueous media: F.A. Villamena, et al.; J. Phys. Chem. (A) 107, 4407 (2003),
2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties: G. Olive, et al.; Free Radic. Biol. Med. 28, 403 (2000), Abstract;
Detection of superoxide anion using an isotopically labeled nitrone spin trap: potential biological applications: H. Zhang, et al.; FEBS Lett. 473, 58 (2000), Abstract;

Related Products

DEPMPO 

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ALX-430-093-M050 50 mg 180.00 USD
 
ALX-430-093-M500 500 mg 1,403.00 USD
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DMPO 

Spin trapping reagent
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ALX-430-090-M500 500 mg 152.00 USD
 
ALX-430-090-G001 1 g 247.00 USD
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