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2-Phthalimidino-glutaric acid

Antitumor agent
 
ALX-430-097-M005 5 mg 41.00 USD
 
ALX-430-097-M025 25 mg 164.00 USD
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Stable analog of thalidomide with increased antitumor (antimetastatic) potency.

Product Specification

Formula:C13H13NO5
 
MW:263.3
 
Purity:≥96%
 
Appearance:White powder.
 
Solubility:Soluble in DMSO or methanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-430-097
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ALX-430-097

Product Literature References

Antiangiogenic activity of tumor necrosis factor-alpha production regulators derived from thalidomide: R. Shimazawa, et al.; Biol. Pharm. Bull. 22, 224 (1999), Abstract;
Synthesis and enantiomeric separation of 2-phthalimidino-glutaric acid analogues: potent inhibitors of tumor metastasis: J.H. Shah, et al.; J. Med. Chem. 42, 3014 (1999), Abstract;
Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species-dependent: K.S. Bauer, et al.; Biochem. Pharmacol. 55, 1827 (1998), Abstract;
Thalidomide. A surprising recovery: D. Stirling, et al.; J. Am. Pharm. Assoc. NS37, 306 (1997), Abstract;
The effect of thalidomide on experimental tumors and metastases: A.I. Minchinton, et al.; Anticancer Drugs 7, 339 (1996), Abstract;
Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes: E.P. Sampaio, et al; J. Exp. Med. 173, 699 (1991), Abstract;

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