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United States 

POBN (high purity)

Spin trapping reagent
 
ALX-430-091-M500 500 mg 149.00 USD
 
ALX-430-091-G001 1 g 230.00 USD
 
Cell permeable hydrophilic spin trap for both in vivo and in vitro studies. Water soluble analog of PBN (Prod. No. ALX-430-082). Low paramagnetic impurities. No further purification required.

Product Specification

Alternative Name:α-(4-Pyridyl 1-oxide)-N-tert-butylnitrone
 
Formula:C10H14N2O2
 
MW:194.2
 
CAS:66893-81-0
 
Purity:≥99% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White to off-white or colorless crystalline solid.
 
Solubility:Soluble in DMSO, water, methanol or 100% ethanol.
 
Long Term Storage:-20°C
 
ALX-430-091
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ALX-430-091

Product Literature References

Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis: K. Stadler, et al.; Am. J. Phys. Endocrin. Metab. 295, E456 (2008), Abstract;
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes: K. Stadler, et al.; Free Radic. Biol. Med. 45, 866 (2008), Abstract;
Identification of free radical formation and F2-isoprostanes in vivo by acute Cr(VI) poisoning: M.B. Kadiiska, et al.; Chem. Res. Toxicol. 11, 1516 (1998), Abstract;
The spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone stimulates peroxidase-mediated oxidation of deferoxamine. Implications for pharmacological use of spin-trapping agents: M.L. McCormick, et al.; J. Biol. Chem. 270, 29265 (1995), Abstract; Full Text
Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells: L.S. Alexander-North, et al.; J. Lipid Res. 35, 1773 (1994), Abstract;
In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study: L. Goria-Gatti, et al.; Carcinogenesis 13, 799 (1992), Abstract;
Two decades of spin trapping: E.G. Janzen & D.L. Hare; Adv. Radic. Chem. 1, 253 (1990),

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